nufense

Grounds of creation

The creation of our Mycotoxin Management Solutions stems from a vital need to protect animal health and enhance productivity. Mycotoxins are harmful substances produced by fungi commonly found in animal feed. Mycotoxin-producing fungi can be divided into two classes: field and storage fungi. Field fungi, such as Fusarium species, produce mycotoxins during their growth in the field. Storage fungi, such as Aspergillus and Penicillium species, produce mycotoxins after crop harvest.

The major harmful mycotoxins commonly found in feed are: Aflatoxins, Deoxynivalenol, Ochratoxin, Zearalenone, Fumonisins, T-2 and HT-2. These toxins can seriously affect animal health, leading to poor growth, weakened immunity, and many other symptoms, which in turn reduce productivity and increase production cost. Up until now, over 400 mycotoxins with toxic potential have already been described, highlighting the extensive challenge that mycotoxin contamination poses to animal health and productivity.

Mycotoxins’ presence has been associated with negative effects on immune competences and gut integrity.

The concentration, chemical composition and synergistic effects of various mycotoxins contribute to the adverse symptoms in growing animals and reproductive animals, which are exposed fpr longer periods.

At moderate to more elevated levels, Aflatoxin B1, Ochratoxin, Fumonisins and Trichothecenes such as DON, and T2, have been shown to impair gut health and cellular membrane integrity, reduce nutrient absorption, increase oxidative stress and to inhibit the synthesis of protein molecules such as immunoglobulins.

Why Mycotoxin Management is vital:

Healthier Animals

Mycotoxins can cause various health problems, such as liver damage, immune suppression, and even death in severe cases. By reducing these toxins in feed, you can sustain healthier livestock. Studies have shown that mycotoxins like aflatoxins and ochratoxins can induce oxidative stress, disrupt antioxidant defenses, and cause significant damage to the liver and kidneys, impacting overall animal health.

Improved Productivity

Healthy animals grow better, reproduce more efficiently, and produce more milk, eggs, or meat. Research indicates that mycotoxin contamination can reduce feed intake, nutrient digestibility and gut health, which directly impacts growth and production.

Cost Savings

Dealing with sick animals adds unnecessary costs due to veterinary treatments and loss of productivity. With nuFense Mycotoxin Management Solutions, you can avoid these costs by enhancing animal health from the start. Effective mycotoxin control can prevent significant economic losses.

Food Safety

Mycotoxins in animal feed can transfer to animal products consumed by humans, such as milk and eggs. It is important to ensure feed is safe, as mycotoxins pose a risk not only to animal health but also to human health through the food chain.

Sustainability

Healthy animals make more efficient use of feed, leading to less waste and more sustainable farming practices.

We have created a product that protects animal health and productivity, reduces costs, promotes food safety, and supports sustainable farming. A product that pays off in a smart way by addressing the critical issue of mycotoxin contamination and enhancing the success and profitability of animal production.

Principles for Mycotoxin Management

Our mycotoxin management solution is crafted on foundational principles that ensure the highest standards of safety and effectiveness.

Our approach to mycotoxin management is grounded in cutting-edge scientific research. We leverage the latest findings and technologies to develop solutions that not only combat mycotoxins effectively, but do so in a way that supports animal health and productivity.

Understanding that mycotoxins pose a serious risk to animal health and the food supply chain, we take a holistic approach to management. Our solution is designed to not only minimize the effects of mycotoxins, but also to support the overall animal health.

nufense fighting against harmful factors

What Are Mycotoxins?

Mycotoxins are harmful substances produced by certain types of molds found in feed and grains. These toxins can negatively affect the health and productivity of animals, especially young ones and those exposed for longer periods.

How Do Mycotoxins Affect Animals?

Mycotoxins can damage the gut and weaken the immune system of animals. This can lead to:

Specific mycotoxins are particularly harmful. They disrupt the gut’s ability to function properly, by reducing the absorption and digestibility of nutrients and increasing the risk of severe infections.

Destructive Factors in Numbers:

A meta-analysis study reviewed 98 scientific papers involving 1401 different diets to assess the impact of mycotoxins on broilers. The results are significant and underscore the importance of effective mycotoxin management:

These statistics highlight how mycotoxins can severely impact the growth and health of broilers, affecting their productivity and increasing mortality rates. Mycotoxin contamination leads to decreased feed intake and weight gain, while causing a significant increase in stress and inflammation levels in vital organs like the liver and kidneys.

nufense: Your Solution to Combat Mycotoxins

Our mycotoxin management solution, nufense, is designed to ensure healthier animals, improved productivity, cost savings, feed safety, and sustainability. By investing in nufense, you are safeguarding the health of your animals and ensuring your profitability.

Our Integrated Approach

To effectively combat mycotoxins, an integrated approach is essential. This includes both physical (adsorption) and biological (degradation and deactivation) methods.

Ηere’s how nufense works to protect:

• As mycotoxin binder, thus mycotoxins adsorption rate is increased and they are excreted from the body.
• As mycotoxin modifier, thus mycotoxins are transformed into non-toxic and non-adsorbable molecules and are excreted from the body.

With nufense, the animals are protected against the harmful effects of mycotoxins, leading to better health, improved productivity, and reduced costs. Our solution ensures a comprehensive approach to mycotoxin management, supporting the overall animal health and productivity.

The blend of mineral clays used is involved in many biochemical processes through ion exchange, adsorption and catalysis with highly adsorption capacity and enhanced hydrophilic (anti-diarrhea) and oleophilic (toxin-binding) activity.

In addition, nufense mineral clay has an adsorption activity against enterotoxins (Enterotoxinogenic E. coli) and decomposition of protein products (reduction of NH₃ emissions in the environment). The major property of aluminosilicate clay is to protect animal’s GIT from mycotoxins present in the feed.

Biologically specific active enzymes deactivate mycotoxins (such as OTA, DON, T-2, FUM, ZEN) by biotransformation and biodegradation in the GIT.

Dry Yeast Cell wall is a premium yeast fraction rich in β-glucans and mannan-oligosaccharides (MOS).

It prevents colonization of the GIT by pathogens, stimulates the immune activity of the phagocytic cells, and enhances the activity of beneficial bacteria, such as Lactobacillus and Bifidobacterium, creating an immunological wall against diseases.

nufense contains yeast of exceptional quality, produced in a challenging environment aiming at ethanol production and is not a byproduct of brewery or bakery industry. The yeast culture passes through numerous fermentation cycles, so the Yeast Cell wall becomes much denser with the highest β-glucans concentration and lower fat content in its composition, so it is less digestible in the intestinal tract.

Mycotoxins not only reduce animal performance, but they also cause significant liver damage. Aflatoxins have a hepatotoxic effect in chickens and a hepatocarcinogenic effect in exposed animals. The Liver tonic used is based on Silymarin (Milk Thistle extract), an antioxidant that protects the liver from the free radical damage produced by mycotoxins.

nufense: Questions & Answers

For your orders, additional information and specifications contacts us at info@nuevo-group.com

nufense product range uses and forms

nufense: the proοfs of effectiveness

We have a comprehensive report on nufense’s mycotoxin elimination effectiveness from the University of Veterinary Medicine Budapest, along with a certificate of analysis from Trilogy Analytical Laboratory. Here’s the conclusion of what was found:

Trilogy Analytical Laboratory:

• Purpose: To test nufense efficiency to adsorb mycotoxins from feed.
• Method:
o Tested feed at pH levels 3 and 6.5.
o Used chromatographic analysis to measure remaining mycotoxins.
o Calculated elimination percentage by comparing treated and untreated feed.

Key Findings:

• High Elimination Rates: 99,6% of aflatoxin and 71.2% of zearalenone were eliminated.
• Synergy: Combines ingredients for better elimination.

University of Veterinary Medicine Budapest:

• Purpose: To test nufense efficiency to deactivate mycotoxins from feed.
• Method:
o Tested feed at pH levels 4.5 and 7.5.
o Incubation times: 0, 30, 60, 120, 240, and 300 minutes.
o Used chromatographic analysis to measure remaining mycotoxins.
o Calculated elimination percentage by comparing treated and untreated feed.

Key Findings:

• High Elimination Rates: Over 90% of all tested mycotoxins were eliminated.
• Example: Aflatoxin reduced by over 95% in 30 minutes.
• Consistency: Works well in both broiler and layer feeds.
• Synergy: Combines ingredients for better elimination.

Detailed Results:

• Elimination Percentages:
o DON: ~96% at pH 4.5, ~92% at pH 7.5
o Fumonisin: ~93.8% at pH 4.5, ~91% at pH 7.5
o Aflatoxin: ~98% at both pH levels
o Ochratoxin: ~94.5% at pH 4.5, ~90% at pH 7.5
o T-2 toxin: 100% at pH 4.5, ~96.4% at pH 7.5

Takeaways:

• Effectiveness: >90% elimination of mycotoxins.
• Robustness: Effective across different pH levels.
• Synergy: Combines ingredients work better together.
• Consistency: Effective in both broiler and layer feeds.

This shows that nufense is a reliable and effective product for reducing mycotoxins’ negative impacts, helping to keep livestock healthy.

Indicative references

• Mavrommatis, A., Giamouri, E., Tavrizelou, S., Zacharioudaki, M., Danezis, G., Simitzis, P. E., Zoidis, E., Tsiplakou, E., Pappas, A. C., Georgiou, C. A., & Feggeros, K. (2021). Impact of Mycotoxins on Animals’ Oxidative Status. Antioxidants, 10(2), 214. https://doi.org/10.3390/

• Xu, R., Kiarie, E.G., Yiannikouris, A. et al. Nutritional impact of mycotoxins in food animal production and strategies for mitigation. J Animal Sci Biotechnol 13, 69 (2022). https://doi.org/10.1186/s40104-022-00714-2

• Gao Y, Meng L, Liu H, Wang J, Zheng N. The Compromised Intestinal Barrier Induced by Mycotoxins. Toxins (Basel). 2020 Sep 28;12(10):619. doi: 10.3390/toxins12100619. PMID: 32998222; PMCID: PMC7600953